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KMID : 0352819890050020075
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Kosin Medical Journal
1989 Volume.5 No. 2 p.75 ~ p.92
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Indium-111 Labeling of Mixed leukocyes and Platelets by 2-Mercaptopyridine-N-Oxide(Merc) and its Clinical Utility
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Abstract
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In-111 leukocytes and platelets were labeled with Mercaptopy riding-N-oxide(Merc) by modified Thakur´s in 14 cases. Simplified cell labeling technique was described. The labeling efficiency of In-111 merc leukocyte with heparin anticoagulants yield average 71% in 12 cases and labeling of In-111 platelets with ACD anticoagulant yield 88% in 2 cases.
In-111 leukocye scintigraphy exhibited strong positive accumulation of radioactivity in acute or active process site of osteomyelitis and weak or poor accumulation of nonactive or chronic inflammatory site or resolving site of osteomyelitis, differed from 3 staged bone scan exhibiting increased blood flow perfustion and uptake on delayed static bone scan indifferentially.
In-111 plateles scintigraphy depicted active process of acute thrombophlebitis but no occluded vessel even though it had thromosis. Chronic liver abscess and acute cholecystitis with empyema were negative of In-111 leukocyte scintigraphy. However further more studies were required to obtained pertinent conclusion.
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